To reduce your threat, your doctor must have you go ahead and take smallest dose that actually works, and take it with the shortest achievable time. See also The best way to Use part To learn more about addiction.

Codeine and promethazine, two with the Lively substances in Promethazine HCl and Codeine Phosphate Oral Solution, may create marked drowsiness and impair the mental and/or Actual physical abilities needed for your overall performance of doubtless hazardous tasks including driving a car or operating equipment. Recommend clients to avoid participating in dangerous responsibilities requiring psychological alertness and motor coordination immediately after ingestion of Promethazine HCl and Codeine Phosphate Oral Resolution.

Tend not to drink Alcoholic beverages or use prescription or in excess of-the-counter medicines that include Alcoholic beverages. Making use of Liquor while getting promethazine/codeine could cause you to definitely overdose and die.

The narcotic antagonist, naloxone hydrochloride, might be administered when substantial respiratory melancholy occurs with promethazine and codeine; any depressant outcomes of promethazine are usually not reversed with naloxone. Diazepam might be utilized to control convulsions. Stay clear of analeptics, which may cause convulsions. Acidosis and electrolyte losses really should be corrected. A rise in temperature or pulmonary difficulties may possibly signal the need for establishment of antibiotic therapy.

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Nursing moms getting codeine can even have greater morphine degrees of their breast milk If they're ultra-speedy metabolizers. These bigger amounts of morphine in breast milk may possibly lead to life-threatening or deadly Unwanted effects in nursing babies. Instruct nursing mothers to watch for here indications of morphine toxicity of their infants such as elevated sleepiness (over usual), issues breastfeeding, respiration complications, or limpness.

Hemodialysis is not really routinely applied to boost the elimination of codeine or promethazine from your body.

, ritonavir) or discontinuation of the cytochrome P450 3A4 inducer such as rifampin, carbamazepine, and phenytoin, may perhaps bring about an increase in codeine plasma concentrations with subsequently increased metabolism by cytochrome P450 2D6, leading to higher morphine amounts, which could increase or extend adverse reactions and could induce potentially lethal respiratory melancholy.

This quick conversion brings about larger than predicted serum morphine levels. Even get more info at labeled dosage regiments, individuals who are ultra-quick metabolizers may expertise overdose indications such as Intense sleepiness, confusion, and shallow breathing.

Pregnancy. Promethazine/codeine may possibly lead to damage to an unborn little one. Explain to your healthcare service provider if you are or strategy get more info to become pregnant. Your Health care company will suggest you if you must just take promethazine/codeine while you're pregnant or seeking to get Expecting.

See dosage Directions higher than or talk to the solution label to ascertain the appropriate dosage for yourself.

Significant Allergic Reactions. check here Promethazine/codeine may induce allergic reactions, which may be significant. Prevent taking promethazine/codeine and obtain aid instantly Should you have any of the following check here signs or symptoms of a significant allergic response.

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The concomitant utilization of opioids with other medicine that have an affect on the serotonergic neurotransmitter method has resulted in serotonin syndrome.